Archives     Advertise     Editorial Calendar     Subscribe     Contact Us    


Landmark Vanderbilt Studies Find IV Saline Less Beneficial Than Balanced Fluids for Patient Survival


 

Vanderbilt University Medical Center is encouraging its medical providers to stop using saline as intravenous fluid therapy for most patients, a change provoked by two companion landmark studies released today that are anticipated to improve patients' survival and decrease kidney complications.

Saline, used in medicine for more than a century, contains high concentrations of sodium chloride, which is similar to table salt. Vanderbilt researchers found that patients do better if, instead, they are given balanced fluids that closely resemble the liquid part of blood.

"Our results suggest that using primarily balanced fluids should prevent death or severe kidney dysfunction for hundreds of Vanderbilt patients and tens of thousands of patients across the country each year," said study author Matthew Semler, MD, MSc, assistant professor of Medicine at Vanderbilt University School of Medicine.

"Because balanced fluids and saline are similar in cost, the finding of better patient outcomes with balanced fluids in two large trials has prompted a change in practice at Vanderbilt toward using primarily balanced fluids for intravenous fluid therapy."

The Vanderbilt research, published today in the New England Journal of Medicine, examined over 15,000 intensive care patients and over 13,000 emergency department patients who were assigned to receive saline or balanced fluids if they required intravenous fluid.

In both studies, the incidence of serious kidney problems or death was about 1 percent lower in the balanced fluids group compared to the saline group.

"The difference, while small for individual patients, is significant on a population level. Each year in the United States, millions of patients receive intravenous fluids," said study author Wesley Self, MD, MPH, associate professor of Emergency Medicine.

"When we say a 1 percent reduction that means thousands and thousands of patients would be better off," he said.

The authors estimate this change may lead to at least 100,000 fewer patients suffering death or kidney damage each year in the US.

"Doctors have been giving patients IV fluids for over a hundred years and saline has been the most common fluid patients have been getting," said study author Todd Rice, MD, MSc, associate professor of Medicine.

"With the number of patients treated at Vanderbilt every year, the use of balanced fluids in patients could result in hundreds or even thousands of fewer patients in our community dying or developing kidney failure. After these results became available, medical care at Vanderbilt changed so that doctors now preferentially use balanced fluids," he said.

 
Share:

Related Articles:


Recent Articles

Alexander: Bipartisan Legislation Will Lower What Americans Pay Out of Their Own Pockets for Health Care

The Lower Health Care Costs Act of 2019 contains nearly three dozen proposals from at least 16 Republican, 14 Democrat senators

Read More

If You Build It, They Will Come

Middle Tennessee's healthcare options continue to expand through new construction and facility renovations and additions.

Read More

Lease, Build, Buy, Sell: Finding the Best Fit for Each Medical Practice

When it comes to medical real estate, there is no one 'right' answer for every practice. Instead, experts say it's important to understand all the options before making a decision that impacts individual physicians, the practice ... and ultimately, patients.

Read More

Dr. Jerry Tannenbaum: Redefining, Redesigning Nephrology

Innovative building models and telemedicine mean better care for patients nationwide.

Read More

Wayfinding in Healthcare

With expansions, renovations and additions to healthcare facilities over time, the ability to easily navigate a campus is often lost along the way. Taking time to consider wayfinding can vastly improve the way patients, visitors and staff engage with the environment.

Read More

Building Walls

Steve Ward & Associates prefab headwalls mean more savings, options for healthcare clients.

Read More

LipiFlow®: Advanced Procedure to Treat Meibomian Gland Dysfunction & Chronic Dry Eye

In-office procedure can promote eyelid health and provide relief from dry eye.

Read More

SCALE 2019 Showcases Latest in Aesthetics Medicine

Now in its 14th year, the Music City SCALE Conference broke previous attendance records, with plans for additional growth in 2020.

Read More

Rethinking the Approach to Acne

New options and research have changed the traditional approach to treating acne.

Read More

Financing the Deal

Healthcare investment experts gathered for the Nashville Health Care Council's annual Financing the Deal panel focused on private equity trends and strategies.

Read More

Email Print
 
 

 

 


Tags:
None
Powered by Bondware
News Publishing Software

The browser you are using is outdated!

You may not be getting all you can out of your browsing experience
and may be open to security risks!

Consider upgrading to the latest version of your browser or choose on below: