Archives     Advertise     Editorial Calendar      Advertiser Index     Subscribe     Contact Us    


People at High Genetic Risk for Colorectal Cancer Benefit More From Lifestyle Changes


 
Wei Zheng, MD, PhD

People with a high polygenic risk score for colorectal cancer could benefit more at preventing the disease by leading healthy lifestyles than those at lower genetic risk, according to a study by Vanderbilt researchers published in The American Journal of Clinical Nutrition.

Analyzing data from participants in the UK Biobank, the researchers estimated that maintaining a healthy lifestyle was associated with a nearly 40% reduction in colorectal cancer risk among those with a high genetic risk of developing the disease. The percentage dropped to only about 25% among people at a low genetic risk for this cancer. People with a high genetic risk and an unhealthy lifestyle were more than three times as likely to be diagnosed with colorectal cancer than those with a low genetic risk and a healthy lifestyle.

"Results from this study could be useful to design personalized prevention strategies for colorectal cancer prevention," said Wei Zheng, MD, PhD, MPH, Anne Potter Wilson Professor of Medicine and associate director for Population Sciences Research at Vanderbilt-Ingram Cancer Center (VICC).

In the analysis, lifestyle scores of unhealthy, intermediate and healthy were determined according to waist-to-hip ratio, physical activity, sedentary time, processed and red meat intake, vegetable and fruit intake, alcohol consumption and tobacco use. Polygenic risk scores are used to measure genetic susceptibility to colorectal cancer. Vanderbilt researchers constructed polygenic risk scores using genetic variants associated with colorectal cancer risk identified in recent large genetic studies including more than 120,000 study participants. They also constructed polygenetic risk scores for several other common cancers in research that was published last year in JNCI Cancer Spectrum.

The recently published study in The American Journal of Clinical Nutrition is one of the few that quantifies potential interactions of overall lifestyle with genetic susceptibility to colorectal cancer.

The study's other authors are Jungyoon Choi, M.D, Guochong Jia, MPH, Wanqing Wen, MD, MPH, research associate professor of Medicine and Xiao-Ou Shu, MD, PhD, Ingram Professor of Cancer Research.

The research was supported in part by funds provided by the Anne Potter Wilson chair endowment at Vanderbilt University and a research grant from the National Cancer Institute.

 
Share:

Related Articles:


Recent Articles

Answering the Call to Train More Physicians

Local healthcare leaders address the growing need for doctors nationwide

Read More

Back to School with COVID

After enjoying a taste of 'return to normal' earlier this year, the Delta variant has changed the trajectory of the pandemic and plunged communities into crisis again.

Read More

Addressing Kids' Health in Tennessee

New plans designed to impact social determinants of health among Tennessee's kids

Read More

ACS Updates Children's Surgery Verification Program Standards

Updated standards from ACS Children's Surgery Verification Program emphasize new patient care expectations for participating hospitals.

Read More

Q&A with New Nashville Health Care Council Fellows Director Lydie Marc

Meet the Nashville Health Care Council's new Fellows Director Lydie Marc and hear about plans for the upcoming session.

Read More

An Innovator in Joint Replacement

TriStar Centennial orthopaedist Dr. Jeff Hodrick is proving less is more when it comes to pain relief.

Read More

News of Note in Orthopaedics & Pain Management

New providers, centers and services give Middle Tennessee patients more option for pain relief and care.

Read More

An Integrative Approach to Pain Management

Patients benefit when providers work together

Read More

Medicare ACOs Increased Savings for Seventh Straight Year

Medicare's largest alternative payment model produced its highest annual savings to date in 2020, while continuing to provide high-quality care, as shown by performance data released today by the Centers for Medicare & Medicaid Services (CMS).

Read More

Supporting Value in Healthcare for All

While the move to value-based care continues to progress, healthcare groups look for more supports and fix to 'rural glitch.'

Read More

Email Print
 
 

 

 


Tags:
None
Powered by Bondware
News Publishing Software

The browser you are using is outdated!

You may not be getting all you can out of your browsing experience
and may be open to security risks!

Consider upgrading to the latest version of your browser or choose on below: